Development of novel vaccine vectors | 台北市立動物園資訊網
由JGuo著作·2018·被引用17次—Thechimpanzeeadenovirus-basedvectorisonekindofnovelvaccinecarrierswhoseuniquefeaturesandnon-reactivitytopre-existinghumanadenovirus ...
IntroductionAdenoviruses (Ads) are non-enveloped, icosahedral, double-stranded DNA viruses that can broadly infect vertebrates including humans and non-human primates.Citation 1[1] Adenovirus was first discovered in 1953.Citation2[2] Most efforts have previously focused on human Ad serotype 5 (AdHu5)-based vectors, which have been extensively studied in laboratories and clinical trials over the past decades.Citation3[3] It was demonstrated that the AdHu5 vector can elicit potent antigen-specific immune responses in both preclinical and clinical studies.Citation3-5[4] Although the AdHu5 vector was shown to be very efficient, AdHu5 infection is endemic in humans. In America, 40–60% of humans carry detectable neutralizing antibodies (NAs) against AdHu5 wild-type virus.Citation6[5] The high prevalence of AdHu5 NAs within the human population reduces the efficiency of gene transfer by the vector and im...
Development of novel vaccine vectors ... | 台北市立動物園資訊網
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Development of novel vaccine vectors | 台北市立動物園資訊網
【人猿】:人猿人科;極危 CR
粗糙而稀疏的毛顏色會隨著年齡改變,從幼年鮮明的橘色到成年動物的紅褐色,有些還會轉變成深巧克力色。額頭高,鼻口凸出。手...
【黑猩猩】:;瀕臨絕種保育類野生動物
臉部為黑色無毛鬚,眉脊隆起;頭部有毛髮,成年後會略禿;小黑猩猩的鼻子、耳朵、手掌及腳掌為肉色,身體部份的膚色則每一隻...